Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models
Given mounting evidence for adverse effects from excess manganese exposure, it is critical to understand host factors, such as genetics, that affect manganese metabolism. This research paper by Jonghan Kim Birgit Claus Henn, Marianne Wessling-Resnick, Martha María Téllez-Rojo, Innocent Jayawardene, Adrienne S Ettinger, Mauricio Hernández-Avila, Joel Schwartz, David C Christiani, Howard Hu and Robert O Wright of the Departments of Genetics and Complex Diseases and Environmental Health, Harvard School of Public Health, Boston, Massachusetts, evaluates associations of manganese with functional variants in three candidate iron metabolism genes.
Influence of DMT1 and iron status on inflammatory responses in the lung
Research paper by Jonghan Kim, Ramon M. Molina, Thomas C. Donaghey, Peter D. Buckett,, Joseph D. Brain and Marianne Wessling-Resnick of the Departments of Genetics and Complex Diseases and Environmental Health, Harvard School of Public Health, Boston, Massachusetts
Will New Cellular Models of Parkinson’s Disease Advance Understanding of Disease and Therapy?
To date, a model for Parkinson’s disease (PD) that accurately replicates key features of pathophysiology represents a major bottleneck in the understanding of disease mechanisms, as well as in efficient drug screening. Both cell culture systems and animal models of PD have fundamental limitations in that none of these models faithfully recapitulates all of the clinical and pathological phenotypes that define the disease. Effectively modelling disease progression, with reproduction of pathological hallmarks of the disease, such as Lewy bodies, poses significant challenges to the development of an animal or cellular model of PD. Read more in this report by Birgitt Schüle, Assistant Professor and Clinical Molecular Geneticist of The Parkinson’s Institute and Clinical Center.